Anti-Corrosion Alcohol Deposition Tank for Pharma

Product Overview

The Anti-Corrosion Alcohol Deposition Tank for Pharma sets the industry standard for precision separation in pharmaceutical manufacturing, specifically engineered for alcohol precipitation processes critical to herbal extract purification. Constructed with 316L stainless steel featuring a specialized anti-corrosion passivation treatment, this tank provides exceptional resistance to ethanol and hydroalcoholic mixtures up to 95% concentration. Available in working volumes from 500L to 5000L, it features a conical-bottom design with precise temperature control (5-25°C with ±0.5°C accuracy) to optimize precipitation efficiency and particle size uniformity. Fully compliant with 2025 GMP standards and EU 2025/351 regulations, the tank integrates advanced mixing technology with sanitary design elements, ensuring Class 8 cleanroom compatibility for sensitive pharmaceutical applications. Its unique jacketed cooling system combined with overhead agitation ensures uniform supersaturation conditions, critical for consistent API (Active Pharmaceutical Ingredient) purification.

Product Features

Superior Corrosion Resistance

• 316L stainless steel construction with enhanced molybdenum content (2.5%) for alcohol resistance

• Specialized electropolishing treatment (Ra 0.8μm) creating passive oxide layer

• Welded joints with post-weld passivation ensuring uniform corrosion resistance

• Compatible with ethanol concentrations from 30% to 95% and aqueous alcohol mixtures

Precision Temperature Control

• Dual-zone jacketed cooling system with ±0.5°C temperature uniformity

• Refrigeration capacity of 15-150 kW depending on tank size

• Programmable cooling rates (0.5-2°C per hour) for controlled precipitation

• Insulated exterior with minimal heat loss (<1°C per hour at 5°C)

Optimized Agitation System

• Low-shear anchor agitator with variable speed control (5-30 rpm)

• Sweep blades reaching within 3mm of tank walls to prevent localized supersaturation

• Intermittent agitation programming to balance particle growth and suspension

• Sealed agitator shaft with pharmaceutical-grade mechanical seals (FDA CFR 177.2600 compliant)

GMP-Compliant Design

• Crevice-free internal surfaces with continuous welds and blended corners

• Full CIP/SIP capability with rotating spray ball and dedicated cleaning cycles

• Sanitary tri-clamp connections for all ports and sensors

• Sight glass with light fixture for visual inspection of precipitation

Applications

Herbal Medicine Purification

• TCM (Traditional Chinese Medicine) extract alcohol precipitation

• Botanical API purification and concentration

• Polysaccharide and glycoside separation

• Flavonoid and alkaloid isolation

Pharmaceutical Manufacturing

• Excipient purification processes

• Colloid and suspension stabilization

• Protein precipitation and purification

• Impurity removal from liquid formulations

Biopharmaceutical Processing

• Vaccine purification steps

• Monoclonal antibody fractionation

• Peptide isolation processes

• Biopolymer concentration and purification

The tank's precise temperature control and gentle agitation make it particularly suitable for producing uniform precipitates with consistent particle size distributions, critical for downstream filtration and drying processes.

FAQ

What alcohol concentrations can it handle?

The tank is specifically engineered for alcohol concentrations from 30% to 95% ethanol, the typical range used in pharmaceutical precipitation processes. The 316L stainless steel construction with specialized passivation provides excellent resistance to these concentrations, with no measurable corrosion after 10,000 hours of service in 70% ethanol.

How does it ensure uniform precipitation?

Three key design elements ensure uniformity:

1. Precise temperature control (±0.5°C) preventing localized supersaturation

2. Low-shear agitation ensuring uniform solute distribution without particle damage

3. Controlled cooling rates allowing consistent crystal growth

These features typically result in particle size distributions with CV (coefficient of variation) <20%.

What is the cooling capacity?

Cooling capacities vary by tank size:

• 500L model: 15kW (capable of 5°C temperature drop in 2 hours)

• 1000L model: 30kW

• 2000L model: 60kW

• 5000L model: 150kW

All models can maintain temperatures as low as 5°C even in ambient conditions up to 35°C.

What cleaning procedures are required?

The automated CIP cycle includes:

• Pre-rinse with purified water (5 minutes)

• Alkaline wash with 2% NaOH at 60°C (15 minutes)

• Intermediate rinse (10 minutes)

• Acidic passivation with 1% nitric acid (20 minutes)

• Final rinse with WFI (Water for Injection) (10 minutes)

Total cycle time: approximately 60 minutes, with full documentation for cleaning validation.